RESULTS

業績

  • Neuronal surface antigen-specific immunostaining pattern on a rat brain immunohistochemistry in autoimmune encephalitis.
    Nagata, N., Kanazawa, N., Mitsuhata, T., Iizuka, M., Nagashima, M., Nakamura, M., Kaneko, J., Kitamura, E., Nishiyama, K., Iizuka T
    Front Immunol., 13: 2023,
  • Reversible Brain Atrophy in Cryptogenic New-onset Refractory Status Epilepticus: A Case Report.
    Watanabe T, Nakamori M, Ishikawa K, Motoda A, Neshige S, Yamamoto S, Katahira K, Higaki T, Ueno H, Iizuka T, Maruyama H.
    Intern Med. 2022 Nov 9. 
  • Anti-N-methyl-D-aspartate receptor encephalitis with concurrent human herpes virus-6A deoxyribonucleic acid detection: An autopsy case.
    Shimohama S, Iizuka T, Takizawa T, Watanabe N, Tezuka T, Matsuda K, Yamanoi K, Kanazawa N, Kawamura Y, Yoshikawa T, Suzuki T, Takao M, Nakahara J, Izawa Y.Neuropathology. 2022 Nov 8. d 
  • Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with small cell lung cancer and cytotoxic T-cell-mediated pathology: Case report.
    Akanuma H, Iizuka T, Abe D, Yoshida K, Matsuda N, Sugimoto K, Hashimoto Y, Kanai K.
    Front Immunol. 2022 Aug 19;13:952868. 
  • Paraneoplastic Cerebellar Degeneration With P/Q-VGCC vs Yo Autoantibodies.
    Winklehner M, Bauer J, Endmayr V, Schwaiger C, Ricken G, Motomura M, Yoshimura S, Shintaku H, Ishikawa K, Tsuura Y, Iizuka T, Yokota T, Irioka T, Höftberger R.
    Neurol Neuroimmunol Neuroinflamm. 2022 Jul 7;9(4):e200006. 
  • Immunotherapy-responsive recurrent extensive white matter disease without neuronal or glial surface antibodies: A case report.
    Suga H, Kanazawa N, Nagata N, Nagashima M, Nishiyama K, Iizuka T.
    Neuroimmunology Reports. 2022;2: 100142. 
  • Status epilepticus suspected autoimmune: Neuronal surface antibodies and main clinical features. 
    Suga H, Yanagida A, Kanazawa N, Ohara H, Kitagawa T, Hayashi M, Onozawa Y, Nagata N, Kaneko J, Kitamura E, Nishiyama K, Iizuka T.
    Epilepsia. 2021;62(11):2719-2731. 
  • Severe dysautonomia in glycine receptor antibody-positive progressive encephalomyelitis with rigidity and myoclonus (PERM): A case report.
    Mizutani Y, Adachi S, Nakano S, Hayashi K, Higashi A, Kikuchi K, Maeda T, Murate K, Shima S, Iizuka T, Ueda A, Ito M, Watanabe H.
    Auton Neurosci. 2022 Jan;237:102910. 
  • Thymoma and Autoimmune Encephalitis: Clinical Manifestations and Antibodies.
    Guasp M, Landa J, Martinez-Hernandez E, Sabater L, Iizuka T, Simabukuro M, Nakamura M, Kinoshita M, Kurihara M, Kaida K, Bruna J, Kapetanovic S, Sánchez P, Ruiz-García R, Naranjo L, Planagumà J, Muñoz-Lopetegi A, Bataller L, Saiz A, Dalmau J, Graus F.
    Neurol Neuroimmunol Neuroinflamm. 2021 Jul 23;8(5):e1053. doi: 10.1212/NXI.0000000000001053. 
  • Case Report: Dexmedetomidine for Intractable Clusters of Myoclonic Jerks and Paroxysmal Sympathetic Hyperactivity in Progressive Encephalomyelitis With Rigidity and Myoclonus.
    Fujino Y, Shiga K, Hori M, Tamura A, Iizuka T.
    Front Neurol. 2021 Jul 12;12:703050. doi: 10.3389/fneur.2021.703050. 
  • Gerstmann's Syndrome in a Patient Double-positive for Antibodies against the N-methyl-D-aspartate Receptor and NH2-terminal of α-enolase.
    Sugiyama A, Suzuki M, Suichi T, Uchida T, Iizuka T, Tanaka K, Yoneda M, Kuwabara S.
    Intern Med. 2021 May 1;60(9):1463-1468. doi: 10.2169/internalmedicine.6344-20. Epub 2020 Nov 23. 
  • Clinically based score predicting cryptogenic NORSE at the early stage of status epilepticus.
    Yanagida A, Kanazawa N, Kaneko J, Kaneko A, Iwase R, Suga H, Nonoda Y, Onozawa Y, Kitamura E, Nishiyama K, Iizuka T.
    Neurol Neuroimmunol Neuroinflamm. 2020 Jul 29;7(5):e849. doi: 10.1212/NXI.0000000000000849. 
  • Cerebrospinal fluid MOG-antibodies in anti-NMDA receptor encephalitis with leptomeningeal enhancement.
    Amano E, Machida A, Kanazawa N, Iizuka T.
    Neurol Sci. 2020 Sep;41(9):2635-2638. doi: 10.1007/s10072-020-04343-3. Epub 2020 Apr 3. 
  • A Case of Bilaterally Synchronized Faciobrachial Dystonic Seizures in Anti-Leucine-Rich Glioma Inactivated-1 Encephalitis.
    Mikami T, Amano E, Iizuka T, Machida A.
    Mov Disord Clin Pract. 2020 Mar 31;7(4):470-471. doi: 10.1002/mdc3.12934. 
  • Clinical significance of anti-NMDAR concurrent with glial or neuronal surface antibodies.
    Martinez-Hernandez E, Guasp M, García-Serra A, Maudes E, Ariño H, Sepulveda M, Armangué T, Ramos AP, Ben-Hur T, Iizuka T, Saiz A, Graus F, Dalmau J.
    Neurology. 2020 Jun 2;94(22):e2302-e2310. doi: 10.1212/WNL.0000000000009239. Epub 2020 Mar 11. 
  • Pregnancy outcomes in anti-NMDA receptor encephalitis: Case series.
    Joubert B, García-Serra A, Planagumà J, Martínez-Hernandez E, Kraft A, Palm F, Iizuka T, Honnorat J, Leypoldt F, Graus F, Dalmau J.Neurol Neuroimmunol Neuroinflamm. 2020 Jan 16;7(3):e668. doi: 10.1212/NXI.0000000000000668. 
  • Hashimoto encephalopathy in the 21st century.
    Mattozzi S, Sabater L, Escudero D, Ariño H, Armangue T, Simabukuro M, Iizuka T, Hara M, Saiz A, Sotgiu S, Dalmau J, Graus F.
    Neurology. 2020 Jan 14;94(2):e217-e224. doi: 10.1212/WNL.0000000000008785. Epub 2019 Dec 27. 
  • Focal hyperperfusion and elevated lactate in the cerebral lesions with anti-GABAaR encephalitis: A serial MRI study.
    Ueno H, Iizuka T, Tagane Y, Yamasaki F, Akiyama Y, Hosomi N, Maruyama H.
    J Neuroradiol. 2020 May;47(3):243-246. doi: 10.1016/j.neurad.2019.10.001. Epub 2019 Nov 5. 
  • Autoimmune Encephalitis as an Extra-articular Manifestation of Rheumatoid Arthritis.
    Kitamura E, Kondo Y, Kanazawa N, Akutsu T, Nishiyama K, Iizuka T.
    Intern Med. 2019 Apr 1;58(7):1007-1009. doi: 10.2169/internalmedicine.1846-18. Epub 2018 Nov 19. 
  • Prodromal headache in anti-NMDAR encephalitis: An epiphenomenon of NMDAR autoimmunity.
    Tominaga N, Kanazawa N, Kaneko A, Kaneko J, Kitamura E, Nakagawa H, Nishiyama K, Iizuka T.
    Brain Behav. 2018 Jul;8(7):e01012. doi: 10.1002/brb3.1012. Epub 2018 Jun 1. 
  • Practical issues in measuring autoantibodies to neuronal cell-surface antigens in autoimmune neurological disorders: 190 cases.
    Kaneko J, Kanazawa N, Tominaga N, Kaneko A, Suga H, Usui R, Ishima D, Kitamura E, Akutsu T, Yoshida K, Nishiyama K, Iizuka T.
    J Neurol Sci. 2018 Jul 15;390:26-32. doi: 10.1016/j.jns.2018.04.009. Epub 2018 Apr 8. 
  • Encephalitis with mGluR5 antibodies: Symptoms and antibody effects.
    Spatola M, Sabater L, Planagumà J, Martínez-Hernandez E, Armangué T, Prüss H, Iizuka T, Caparó Oblitas RL, Antoine JC, Li R, Heaney N, Tubridy N, Munteis Olivas E, Rosenfeld MR, Graus F, Dalmau J.
    Neurology. 2018 May 29;90(22):e1964-e1972. doi: 10.1212/WNL.0000000000005614. Epub 2018 Apr 27. 
  • Pitfalls in clinical diagnosis of anti-NMDA receptor encephalitis.
    Kaneko A, Kaneko J, Tominaga N, Kanazawa N, Hattori K, Ugawa Y, Moriya A, Kuzume D, Ishima D, Kitamura E, Nishiyama K, Iizuka T.
    J Neurol. 2018 Mar;265(3):586-596. doi: 10.1007/s00415-018-8749-3. Epub 2018 Jan 22. 
  • Cryptogenic NORSE: Its distinctive clinical features and response to immunotherapy.
    Iizuka T, Kanazawa N, Kaneko J, Tominaga N, Nonoda Y, Hara A, Onozawa Y, Asari H, Hata T, Kaneko J, Yoshida K, Sugiura Y, Ugawa Y, Watanabe M, Tomita H, Kosakai A, Kaneko A, Ishima D, Kitamura E, Nishiyama K.
    Neurol Neuroimmunol Neuroinflamm. 2017 Sep 25;4(6):e396. doi: 10.1212/NXI.0000000000000396. 
  • MOG-IgG-positive multifocal myelitis with intrathecal IgG synthesis as a spectrum associated with MOG autoimmunity: Two case reports.
    Yanagida A, Iizuka T, Nagai T, Usui R, Kaneko J, Akutsu T, Hanajima R, Kanazawa N, Nishiyama K.
    J Neurol Sci. 2017 Nov 15;382:40-43. doi: 10.1016/j.jns.2017.09.020. Epub 2017 Sep 18. 
  • Autoimmune brachial amyotrophic diplegia and sensory neuronopathy with Sjögren's syndrome: A case report.
    Tominaga N, Iizuka T, Kaneko J, Nagai M, Hara A, Onozawa Y, Kanazawa N, Nishiyama K.
    J Neurol Sci. 2016 Sep 15;368:1-3. doi: 10.1016/j.jns.2016.06.053. Epub 2016 Jun 25. 
  • Association of Progressive Cerebellar Atrophy With Long-term Outcome in Patients With Anti-N-Methyl-d-Aspartate Receptor Encephalitis.
    Iizuka T, Kaneko J, Tominaga N, Someko H, Nakamura M, Ishima D, Kitamura E, Masuda R, Oguni E, Yanagisawa T, Kanazawa N, Dalmau J, Nishiyama K.
    JAMA Neurol. 2016 Jun 1;73(6):706-13. doi: 10.1001/jamaneurol.2016.0232. 
  • Clinical and Immunologic Investigations in Patients With Stiff-Person Spectrum Disorder.
    Martinez-Hernandez E, Ariño H, McKeon A, Iizuka T, Titulaer MJ, Simabukuro MM, Lancaster E, Petit-Pedrol M, Planagumà J, Blanco Y, Harvey RJ, Saiz A, Graus F, Dalmau J.
    JAMA Neurol. 2016 Jun 1;73(6):714-20. doi: 10.1001/jamaneurol.2016.0133. 
  • A clinical approach to diagnosis of autoimmune encephalitis.
    Graus F, Titulaer MJ, Balu R, Benseler S, Bien CG, Cellucci T, Cortese I, Dale RC, Gelfand JM, Geschwind M, Glaser CA, Honnorat J, Höftberger R, Iizuka T, Irani SR, Lancaster E, Leypoldt F, Prüss H, Rae-Grant A, Reindl M, Rosenfeld MR, Rostásy K, Saiz A, Venkatesan A, Vincent A, Wandinger KP, Waters P, Dalmau J.
    Lancet Neurol. 2016 Apr;15(4):391-404. doi: 10.1016/S1474-4422(15)00401-9. Epub 2016 Feb 20. 
  • Reversible tongue muscle atrophy accelerated by early initiation of immunotherapy in anti-MuSK myasthenia gravis: A case report.
    Kitamura E, Takiyama Y, Nakamura M, Iizuka T, Nishiyama K.
    J Neurol Sci. 2016 Jan 15;360:10-2. doi: 10.1016/j.jns.2015.11.032. Epub 2015 Nov 18. 
  • Overlapping demyelinating syndromes and anti–N-methyl-D-aspartate receptor encephalitis.
    Titulaer MJ, Höftberger R, Iizuka T, Leypoldt F, McCracken L, Cellucci T, Benson LA, Shu H, Irioka T, Hirano M, Singh G, Cobo Calvo A, Kaida K, Morales PS, Wirtz PW, Yamamoto T, Reindl M, Rosenfeld MR, Graus F, Saiz A, Dalmau J.
    Ann Neurol. 2014 Mar;75(3):411-28. doi: 10.1002/ana.24117. 
  • Late-onset anti-NMDA receptor encephalitis.
    Titulaer MJ, McCracken L, Gabilondo I, Iizuka T, Kawachi I, Bataller L, Torrents A, Rosenfeld MR, Balice-Gordon R, Graus F, Dalmau J.
    Neurology. 2013 Sep 17;81(12):1058-63. doi: 10.1212/WNL.0b013e3182a4a49c. Epub 2013 Aug 14. 
  • Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study.
    Titulaer MJ, McCracken L, Gabilondo I, Armangué T, Glaser C, Iizuka T, Honig LS, Benseler SM, Kawachi I, Martinez-Hernandez E, Aguilar E, Gresa-Arribas N, Ryan-Florance N, Torrents A, Saiz A, Rosenfeld MR, Balice-Gordon R, Graus F, Dalmau J.
    Lancet Neurol. 2013 Feb;12(2):157-65. doi: 10.1016/S1474-4422(12)70310-1. Epub 2013 Jan 3. 
  • Glycine receptor antibodies are detected in progressive encephalomyelitis with rigidity and myoclonus (PERM) but not in saccadic oscillations.
    Iizuka T, Leite MI, Lang B, Waters P, Urano Y, Miyakawa S, Hamada J, Sakai F, Mochizuki H, Vincent A.
    J Neurol. 2012 Aug;259(8):1566-73. doi: 10.1007/s00415-011-6377-2. Epub 2012 Jan 4. 
  • Pseudo-piano playing motions and nocturnal hypoventilation in anti-NMDA receptor encephalitis: response to prompt tumor removal and immunotherapy.
    Uchino A, Iizuka T, Urano Y, Arai M, Hara A, Hamada J, Hirose R, Dalmau J, Mochizuki H.
    Intern Med. 2011;50(6):627-30. doi: 10.2169/internalmedicine.50.4764. Epub 2011 Mar 16. 
  • Reversible brain atrophy in anti-NMDA receptor encephalitis: a long-term observational study.
    Iizuka T, Yoshii S, Kan S, Hamada J, Dalmau J, Sakai F, Mochizuki H.
    J Neurol. 2010 Oct;257(10):1686-91. doi: 10.1007/s00415-010-5604-6. Epub 2010 Jun 2. 
  • Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen.
    Lancaster E, Lai M, Peng X, Hughes E, Constantinescu R, Raizer J, Friedman D, Skeen MB, Grisold W, Kimura A, Ohta K, Iizuka T, Guzman M, Graus F, Moss SJ, Balice-Gordon R, Dalmau J.
    Lancet Neurol. 2010 Jan;9(1):67-76. doi: 10.1016/S1474-4422(09)70324-2. Epub 2009 Dec 2. 
  • Effects of UCH-L1 on a- synuclein overexpression mouse model of Parkinson's disease.
    Yasuda T, Nihira T, Ren YR, Cao XQ, Wada K, Setuie R, Kabuta T, Wada K, Hattori N, Mizuno Y, Mochizuki H.
    J Neurochem 2009 Feb;108(4):932-44
  • Alteration in the differentiation-related molecular expression in the subventricular zone in a mouse model of Parkinson’s disease.
    Oizumi H, Hayashita-Kinoh H, Hayakawa H, Arai H, Furuya T, Ren YR, Yasuda T, Miura M, Mizuno Y, Mochizuki H.
    Neurosci Res 60, 15-21, 2008
  • Relationship of phosphorylated alpha-synuclein and tau accumulation to Abeta deposition in the cerebral cortex of dementia with Lewy bodies.
    Obi K, Akiyama H, Kondo H, Shimomura Y, Hasegawa M, Iwatsubo T, Mizuno Y, Mochizuki H.
    Exp Neurol. 2008 Apr;210(2):409-20.
  • Neurological response to early removal of ovarian teratoma in anti-NMDAR encephalitis. J Neurol Neurosurg Psychiatry.
    Seki M, Suzuki S, Iizuka T, Shimizu T, Nihei Y, Suzuki N, Dalmau J.
    J Neurol Neurosurg Psychiatry. 2008 Mar;79(3):324-6. doi: 10.1136/jnnp.2007.136473. Epub 2007 Nov 21. 
  • Anti-NMDA receptor encephalitis in Japan: long-term outcome without tumor removal.
    Iizuka T, Sakai F, Ide T, Monzen T, Yoshii S, Iigaya M, Suzuki K, Lynch DR, Suzuki N, Hata T, Dalmau J.
    Neurology. 2008 Feb 12;70(7):504-11. doi: 10.1212/01.wnl.0000278388.90370.c3. Epub 2007 Sep 26. 
  • Dopaminergic cell loss in transgenic mice expressing the Parkinson’s disease?associated UCH- L1 I93M mutant.
    Setsuie R, Wang YL, Mochizuki H, Osaka H, Hayakawa H, Ichihara N, Li H, Furuta A, Sato Y, Sun YJ, Kwon J, Kabuta T, Yoshimi K, Mizuno Y, Aoki S, Noda M, Wada K.
    Neurochemistry International 50(1):119-29, 2007
  • Postnatal neurogenesis in hippocampal slicecultures: early in vitro labeling of neuronal precursor cells leads to efficient neuronal production.
    Namba T, Mochizuki H, Onodera M, Namiki H, Seki T.
    J Neurosci Res, 2007 Jun;85(8):1704-12.
  • Clustering, migration and neurite formation of neural precusor cells in the adult rat hippocampus.
    Seki T, Namba T, Mochizuki H, Onodera M.
    J Comp Neurol, 2007 May 10;502(2):275-90.
  • Neuronal specificity of alpha-synuclein toxicity and effect of Parkin co-expression in primates. Neuroscience.144 743-753, 2007
    Yasuda T, Miyachi S, Kitagawa R, Wada K, Nihira T, Ren YR, Hirai Y, Ageyama N, Terao K, Shimada T, Takada M, Mizuno Y, Mochizuki H.
    Neuroscience.144 743-753, 2007
  • Recombinant human granulocyte colony-stimulating factor protects against MPTP-induced dopaminergic cell death in mice by altering Bcl-2/Bax expression levels.
    Cao XQ, Arai H, Ren YR, Ooizumi H, Zhang N, Seike S, Furuya T, Yasuda T, Mizuno Y, Mochizuki H.
    J Neurochemistry 99 861-867, 2006.

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